Knowledge Center › Protocols › Atopic dermatitis and psoriasis
Home protocol · Skin
Atopic Dermatitis and Psoriasis Ozone Protocol
Topical ozone for atopic dermatitis and psoriasis: ozonated oil and ozone water showers and rinses, with a short note on the IV ozone Madrid adds for more severe cases.
Quick answer: At home, topical ozone for atopic dermatitis and psoriasis means ozonated oil on the skin and ozone water showers or rinses. The studies used oil twice a day and water showers 3 to 5 times a week. For more severe cases Madrid adds IV ozone given by a practitioner; see the IV ozone protocol. Test a small area of skin first.
Home method. Best done as recommended by a licensed provider who knows your health history.
What are the basics of ozone for atopic dermatitis and psoriasis?
- Madrid says psoriasis follows generally the same protocol as atopic dermatitis, so they share one sheet here.
- For milder skin concerns Madrid describes topical ozone: water-based sprays, lotions, creams and oils. It gives no strength or schedule for creams, so follow the maker's directions.
- For moderate to severe atopic dermatitis, or mild cases that did not respond to other care, Madrid indicates an IV ozone series given by a practitioner. This sheet shows only its schedule; see the IV ozone protocol for the method and contraindications.
- For psoriasis of the scalp, see the home scalp steps on the fungal skin and nails sheet.
Source: Madrid Declaration on Ozone Therapy, 4th edition (ISCO3, 2025). Paraphrased.
What settings are used for ozone for atopic dermatitis and psoriasis?
| Method | What to do | Settings |
|---|---|---|
| Ozonated oil | A thin layer on the affected skin | Twice a day in the studies. Madrid gives no strength or schedule; follow the maker's directions. |
| Ozone water | Shower or rinse in ozonated water | 3 to 5 times a week in the children's study; strength not known. See the infused water protocol. |
| IV ozone (MAH), practitioner only | Milder cases: once a week for 10 weeks. Moderate to severe: twice a week for 5 weeks, then once a week for 5 weeks. Some cases need a repeat every month or two (Madrid). | Method, dose and contraindications: IV ozone protocol |
What are the best tips when using ozone for atopic dermatitis and psoriasis?
- Start gently and build up. Madrid's general rule is first do no harm.
- Skin care between sessions: a thin layer of ozonated oil, or an ozone water rinse, as on the topical oil and infused water sheets.
What are the precautions for ozone for atopic dermatitis and psoriasis?
- Patch test first: try a small area of skin before wider use.
- Stop if you get irritation, redness or burning.
- Keep oil away from the eyes.
- Do not use on deep or infected wounds without a practitioner.
- Pregnancy: check with your healthcare provider before starting.
- If your practitioner adds IV ozone, its contraindications are on the IV protocol.
More detail
What the studies used
Study doses are listed as printed in each paper and are not Madrid dosing.
- In 65 children aged 8 months to 3 years with extensive atopic dermatitis, adding ozonated olive oil on the lesions twice a day for 15 days, along with rectal ozone, to usual care shortened time to remission from 25.1 to 19.6 days (p<0.001) and lengthened remission from 4.3 to 14.5 months. Groups were not randomized (Illek 2014).
- In 60 children with infantile atopic dermatitis, a shower in ozonated water 3 to 5 times a week plus ozonated oil twice a day for 2 weeks gave an effective rate of 89.6% vs 30.7% with warm water and base oil (p<0.001). Only the abstract is on file, so strengths are not known (Central South Univ Med Sci 2018).
- In 40 adults with stable psoriasis vulgaris, ozonated oil twice a day on one side worked about as well as a steroid ointment on the other by 2 weeks (69.8% vs 70.3% effective), though the steroid was faster at 1 week. Non-randomized, abstract only (Central South Univ Med Sci 2018).
There is no placebo-controlled trial. The evidence is small, uncontrolled or non-randomized.
Learn more
Background, benefits and research: Ozone cream, oil and treatments for skin. Eczema and other immune conditions: Ozone therapy for allergies, asthma and eczema.
Related protocols: Fungal Skin and Nail Infection Ozone Protocol, Acne and Rosacea Ozone Protocol, Minor Autohemotherapy (MiAH) Protocol.
Other skin and related protocols
Educational reference only, not medical advice. Follow local regulations.
