Kevin O'Leary and Ozone Therapy: What He Said About EBOO
Published October 11, 2026 · clip from August 2025
Investor and "Shark Tank" star Kevin O'Leary said in a TV interview that he had EBOO, a clinic-based form of IV ozone therapy, combined with an infusion of 50 billion exosomes during a trip to the Gulf, and that he "walked out of there like a teenager." Here's exactly what he said, what was actually done, and what EBOO involves.
What did Kevin O'Leary say about EBOO?
In a short TV interview clip, O'Leary described the procedure in his own words [1]:
"I got a procedure there we don't offer here. FDA doesn't allow it, called [EBOO], where my blood was filtered and then oxygenated, then ozonated, and then injected with 50 billion exosomes. I walked out of there like a teenager. I feel like a million bucks right now. I said, 'Can I do this again next week?' They said, 'No, you got to wait four more months.'"
What was actually done?
Two treatments in one session, abroad. The first was EBOO: his blood was drawn, filtered, exposed to oxygen and ozone, and returned. The second was an infusion of exosomes, which is a separate treatment and not part of ozone therapy. In a June 2025 interview with Gulf Business, he also described this as part of a longevity routine he follows on visits to the UAE [2].
Because the two were combined, there's no way to tell how much of what he felt came from the ozone part. He's describing one personal experience, and results vary.
His line that "FDA doesn't allow it" is his own characterization. The FDA hasn't approved ozone therapy for any condition, and its well-known "toxic gas" rule is about ozone devices and breathing ozone. We explain what it does and doesn't cover in the FDA "toxic gas" statement, explained.
What is EBOO?
EBOO stands for extracorporeal blood oxygenation and ozonation. Blood is drawn continuously from a vein in one arm, passed through a filter where it's exposed to a measured mix of ozone and oxygen, and returned through the other arm. It's the most intensive form of IV ozone, and it's done only in a clinic by trained staff.
See EBOO: benefits, side effects and cost, and how EBOO compares with other IV methods.
Why do people use ozone therapy for longevity?
The interest comes from how ozone acts in the body. A small, measured dose creates a mild oxidative stress that triggers the body's own antioxidant defenses, and researchers describe effects on circulation and immune signaling. We explain it in plain language in how ozone therapy works.
Studies on ozone therapy for aging itself are limited. Most research looks at specific conditions, and much of it is small. Anyone describing anti-aging results is describing their own experience.
Do you need EBOO to try ozone therapy?
No. EBOO is the most expensive and intensive option. Many people start with simpler clinic methods or with home methods such as rectal insufflation, which cost far less per session. Compare them in IV vs rectal ozone and every home method compared. New to ozone? Begin with Start here.
Practitioners: MediSkill doesn’t teach EBOO. We teach IV ozone therapy using major autohemotherapy (MAH), which we consider the gold standard of IV ozone, in our ozone trainings.
More ozone in the news: Bryce Harper and EBOO and Gwyneth Paltrow on ozone therapy.
MediSkill reports what public figures say about ozone therapy. Their comments are their own and aren't an endorsement of MediSkill.
Sources
- "Kevin O'Leary on EBOO Therapy." TV interview clip (original broadcaster not identified), uploaded to YouTube by the channel “EBOO Medical” on August 29, 2025 (0:55). youtube.com
- Salian N. "From One Development to startup advice: Mr Wonderful Kevin O'Leary dishes out details." Gulf Business, June 16, 2025. gulfbusiness.com
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