Ozone Suppositories (Ozonated Oil): Uses, Side Effects, How to Use

An ozone oil suppository is a hardened ozone oil capsule that is inserted into the rectum or vagina, commonly used for fighting infections.

Ozone oil suppositories have been overlooked by most clinicians, except in the case of vaginal or rectal infections.  

That’s because there is little research on ozonated oil used vaginally or rectally, and none on suppositories themselves. 

So let me break down where else ozone oil suppositories might be of help.

Ozone Oil Suppository Uses

Dr. Velio Bocci writes a positive note about ozone oil suppositories in his book, 

“Moreover I will mention that there are several pharmaceutical vehicles for the administration of ozonated oil, such as gastro-resistant capsules, pessaries, suppositories and even collyriums, to be used in intestinal, vaginal, anal-rectal and ocular infections.”

Clinically, ozone oil suppositories are commonly applied for the following:

• Vaginal Infections
• Rectal Infections
• Colitis
• Fistulas
• Herpes

In the case of herpes, ozone oil suppositories are indicated as a supplement to IV ozone, not a standalone.  

“Local treatment is also important and effective when combined with AHT. It can be performed easily by applying and repeatedly changing a compress moistened with ozonated water and ozonated oil at night. Vaginal or rectal suppositories of ozonated oil can be employed in genital-anorectal herpes.”

In that quote, Dr. Bocci is essentially saying ozone oil suppositories are helpful as an adjunct to treat herpes infections.

If you're dealing with an infection or parasites, it might be worth a try. It’s not considered a replacement for IV, vaginal, or rectal ozone.  

Benefits

Like I said above, there isn’t much scientific literature on ozone oil suppositories.  Most of this comes from anecdotal or clinical reporting.

• May help with infections in the colon, rectum, and vagina
• Some practitioners also use them for parasites, though this hasn’t been studied
• May support the immune response, though their effect is mainly local

While most of the information I have about ozone oil suppositories is anecdotal, I have noticed a very consistent theme with its effectiveness for infections.  Plus there’s a lot of verifiable information about the antiseptic and healing abilities of ozone oil. 

What the evidence shows

There are no published trials of ozone oil suppositories themselves. The closest controlled data is for ozonated olive oil used vaginally as a cream. In a randomized trial of 100 women with vaginal yeast infections, 7 days of ozonated olive oil cleared the infection on culture and relieved itching and discharge about as well as clotrimazole, the standard antifungal cream. Clotrimazole did better for burning (Tara et al., 2016). That was a cream, not a suppository, but it is the same oil in the same place.

The rest of what we know comes from Dr. Bocci’s clinical writing and from practitioners’ experience, along with the well-documented antiseptic and healing properties of ozone oil.

How to use ozone suppositories (rectal and vaginal)

To learn more about protocols and how to use ozone oil suppositories check out this video.

• Storage: keep them in the freezer or fridge. Ozonated oil is soft at room temperature, and freezing makes the suppository firm enough to insert.
• Timing: bedtime works best, because lying down keeps the oil in place longer. Wear a pad or old underwear, since some oil can leak out.
• Rectal use: ideally after a bowel movement. Insert gently, pointed end first.
• Vaginal use: insert while lying down, as you would a tampon or standard vaginal suppository.

Here are common clinical recommendations for ozone oil suppositories.  This is for educational purposes only, so you should talk with your doctor to find what’s right for you.

• Insert ozone oil suppository into the rectum or vagina up to two times daily for a short course. If the problem hasn’t cleared within a couple of weeks, check back with your practitioner rather than continuing on your own.
• For recurrent infections, during times when no infection is present, use 3x weekly as a preventative measure.

Side effects and precautions

• Mild local burning, itching or irritation, especially in the first few uses. If it persists, use them less often or stop.
• Oil leakage, which is harmless but messy.
• Stop and see a doctor if you notice bleeding, worsening pain, fever, or a discharge that changes or gets worse.
• They are not a replacement for diagnosis and treatment of an infection. Get a diagnosed infection treated, and use suppositories alongside that care.
• Don't use them during pregnancy. Our clinic guide lists pregnancy as a contraindication.

Ozone suppositories vs rectal ozone insufflation

Suppositories deliver ozonated oil that works mainly where it is placed: the rectum, the vagina and nearby tissue. Rectal ozone insufflation uses ozone gas, which is absorbed through the colon wall and has whole-body effects, but it needs a generator and oxygen. Many people use suppositories for local problems, or between insufflation sessions, and insufflation when they want a systemic effect. See the rectal insufflation protocol for that method.

How to pick a quality ozone suppository

• The base oil: look for a named oil, usually olive oil, without unnecessary fillers or fragrance.
• How strongly it is ozonated: a reputable maker can tell you the ozonation level, often as a peroxide value. If they can’t, that tells you something.
• Storage and freshness: it should ship cold or with storage instructions, and have a clear expiry date.

New to ozone at home? Our free guide explains the main methods and how to get started safely.

Frequently asked questions

What are ozone oil suppositories?

Ozone oil suppositories are hardened capsules made from ozonated oil that are inserted rectally or vaginally. They are primarily used as a localized approach to help manage infections and support tissue healing.

What are ozone oil suppositories used for?

They are commonly used for vaginal infections, rectal infections, colitis, fistulas, herpes (as an adjunct), and other localized infections where topical ozone oil contact may be beneficial.

Are ozone oil suppositories a replacement for ozone therapy?

No. Ozone oil suppositories are not a replacement for IV, rectal gas, or vaginal ozone therapy. They are typically used as a supportive or adjunctive option alongside other ozone therapies.

What benefits are associated with ozone oil suppositories?

Reported benefits include support against localized infections, potential reduction of parasites, and immune-supportive effects. Much of the evidence is clinical or anecdotal, supported by known antiseptic and healing properties of ozone oil.

How are ozone oil suppositories typically used?

They are usually frozen before use and inserted rectally or vaginally up to two times daily for active issues. For recurrent infections, some practitioners recommend preventive use a few times per week under medical guidance.

Are ozone oil suppositories safe?

There is limited formal research, but clinical experience suggests they are generally well tolerated when used appropriately. Users should consult a qualified healthcare professional, especially for recurrent or severe conditions.